3. I-insulin acts as a growth factor, increases brain energy levels, has effects on numerous neurotransmitters, etc. Due to its many effects, it is very unlikely that it would affect you in the same way that cdp choline, nicotine, or DMAE do. It is possible that i-insulin might raise acetylcholine levels a bit (it’s somewhat of an open question) but your experience with it will likely be very different than with the substances you mentioned. For my part, I also respond very poorly to nicotine even though I do quite well with i-insulin.