Q. I read your review of creatine online and found it
very informational. I am wondering if you can share some information about the
recent body-building supplement Ecdy Bolin. I have been using it for a couple
months (both with creatine and also without). It is promoted as has other
benefits aside from muscle-building, such as nerve function. Anyway, I would
like to know if you feel this supplement is a safe and a quality addition and
how you feel about it in general. At the moment, I am not using creatine, only
A. An internet search reveals Ecdy Bolin has 100 mg of ecdysterone. I have not seen any human studies with Ecdy Bolin or ecdysterone, so I have no opinion on this supplement at this time.
20-Hydroxyecdysone and other ecdysteroids are used in biochemistry research as inducers in transgenic animals, whereby a new gene is introduced into an animal so that its expression is under the control of an introduced ecdysone receptor . Adding or removing ecdysteroids from the animal's diet then gives a convenient way to turn the inserted gene on or off (see ecdysone receptor ). At usual doses, 20-hydroxyecdysone appears to have little or no effect on animals that do not have extra genes inserted; it also has high bioavailability when taken orally, so it is useful for determining whether the transgene has been taken up effectively.  For uses in gene therapy , it may be necessary to investigate more thoroughly the natural sources of ecdysteroids in humans (which appear to include dietary phytoecdysteroids , gut flora , helminth infections , and other diseases ).