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RA-associated glomerulonephritis is often of the mesangioproliferative type, and is less likely to progress to renal failure than the nephritis of systemic lupus erythematosus. 34 Scleritis and peripheral ulcerative keratitis are associated with severe, long-standing joint disease, which may or may not be active, and with ExRA manifestations involving other organs. Patients with RA may also develop milder eye manifestations such as episcleritis, often in the setting of active disease, or keratoconjunctivitis sicca in the setting of secondary Sjögren's syndrome.

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