Steroids post nasal drip

The first line of treatment for nasal polyps is most often steroids which can be given topically or orally. Topical preparations are preferred, but are often ineffective for patients with many polyps. Oral steroids often provide drastic symptom relief, but should not be taken for long periods of time due to their side effects. Patients often have recurrence of symptoms once the steroid medications are stopped. Endoscopic sinus surgery with removal of polyps is often very effective for most patients providing rapid symptom relief. Many physicians recommend a course of oral steroids prior to surgery to reduce mucosal inflammation, decrease bleeding during surgery, and help with visualization of the polyps. Patients often have recurrence of polyps even following surgery. Therefore, continued follow up with a combination of medical and surgical management is preferred for the treatment of nasal polyps. [12]

The major part of the approximately 150 cm 2 surface in the human nasal cavity is covered by respiratory epithelium, across which systemic drug absorption can be achieved. The olfactory epithelium is situated in the upper posterior part and covers approximately 10 cm 2 of the human nasal cavity. The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of all but small, lipophilic substances. However, if drug substances can be transferred along the olfactory nerve cells, they can bypass the BBB and enter the brain directly., [12] [13]

Steroids post nasal drip

steroids post nasal drip


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